Colts vs. 49ers MNF: Key Players Out, Others Questionable - Can Indy Pull Off Upset?

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The Indianapolis Colts (8-6) are gearing up to host Monday Night Football against the San Francisco 49ers (10-4) at Lucas Oil Stadium, marking their first MNF appearance since 2022. However, several crucial players are facing uncertain fates due to injuries. The 49ers will be without wide receiver Ricky Pearsall, who has been ruled out due to a knee and ankle injury suffered against the Tennessee Titans. Pearsall's absence will force the team to adjust their receiving rotation. Cornerback Renardo Green and quarterback Kurtis Rourke will also sit out due to lingering injuries. Yetur Gross-Matos remains questionable with a hamstring injury. Meanwhile, the Colts will be missing cornerback Sauce Gardner, who is out with a calf injury, and quarterback Anthony Richardson, who has been ruled out due to ongoing issues with his eye injury. Other notable absentees include wide receiver Anthony Gould (foot), Safety Daniel Scott (knee), and left tackle Bernhard Raimann (elbow). On the bright side, defensive end DeForest Buckner's return from injured reserve will bolster the Colts' front seven and potentially counterbalance the loss of Sauce Gardner in the secondary. The outcome of this game will be significantly influenced by the participation of these injured players. Will the Colts be able to pull off an upset without key contributors, or will the 49ers' depth prove too much for them to handle?